Elafin and the elastic shape of the gut, are they swarm interactions with the bacteria ?

Elafin has been found to have utility in serving as a biomarker for graft versus host disease of the skin. The protein is expressed in the skin during wound healing through activation of the epidermal growth factor receptor.

One of the scourges of being attacked via inner hospital bugs is becoming infected with Clostridium difficile, a killer bacteria. As horrible as it sounds, treatment using healthy faeces donors can now via faecal transplant make effective possible treatment against those in-house patients infected with Clostridium difficile gut infections.

Our guts harbor a mind numbing 100 trillion bacteria. Human health has evolved in harmony with this symbiotic relationship for a very, very long time. Only now is the actual study of the gut focusing on what is termed hostile bacteria invading into the gut to convert friendly bacteria into hostile bacteria. The conversion of such cellular combat is happening within the very nature of the shape of the gut. Our gut is one long normal elastic tube, lose the critical character within the gut elasticity and hostile invasion has made its beachhead. Treat the gut with healthy bacteria and the hostiles are defeated, the normal elastic character of the gut is recaptured. How can this be ? Let’s investigate the elastic detail further.

The cartoon of elafin as you can see in the first image is a complicated shape for a protein. Don’t forget that proteins are attached in a matrix, so think of looking at a door of a house. It’s not just the door that concerns us as we scan the house’s shape, it’s everything you see leading up to, involving the door-the frame-the wall-the adjacent window-the roof-the eavesdrop, it’s the entire structure not just a single cartoon piece in isolation. Proteins, unlike man-made objects like houses interact with their shape structure into the local structure-into the surrounding structure- it’s a continuum of connections. It’s what I have been trying to elaborate during the past year, it’s a city of structures all linked into connections, its a tensegrity net, a Snelson tensio natat of primed, tension/compression sensing proteins. It’s how Nature distributes shapes into both local, immediate links into larger and larger links in surrounding neigborhoods. Basically someone across the city knows my door is open by feeling their door even though the two houses are miles apart. That is a version of tensegrity in the city, if you like, it’s how cells get the message by physical, mechanical sensing the way Harvard’s Donald Ingber has described it over the years as tensegrity between cells.

This elafin protein shape has to fit into something which is a protein termed the epidermal growth factor receptor. Like a typical tool, our approach  is via dissecting open our elafin shape proteins isolating them away from the connectedness linking the entire structure together. We have doors, that are in  effect, passages into the interior of the tissue creating the cascade of responses.  But with operational tensgrity tensio natat the door changes shape in the protein engaging interaction when passing into its receptor. The gut surfaces have multitudes of these door passages but the responses are like swarm behaviour linking into the entire structure making the best decision in terms of collective output of the elastic shape changes. Restoring the guts elastic  tensio natat character within the gut is the best choice to recreate the swarm behaviour interactions from native gut bacteria.

Cartoon diagram of the epidermal growth factor receptor (EGFR) (rainbow colored, N-terminus = blue, C-terminus = red) complexed its ligand epidermal growth factor (magenta) based on the PDB 1NQL crystallographic coordinates.

Researchers near Cambridge, England at the Wellcome Trust Sanger Institute involving a group headed by Trevor Langley are trying to pinpoint which particular blend of bacteria species could be used instead of the odious transplant method of insertion, being totally discomforting for both the sensibilities of patient and physician. The bacterial cocktail that seems to mimic best the real thing was reported recently in the Public Library of Science using experimental mice. The cocktail also stimulated other gut bacteria that Clostridium difficile was suppressing in addition to replacing friendly with hostile bacteria . Yet the real sad consequences for now are that the United States report over 14 thousand deaths as a result of Clostridium difficile hospital infections.

Anecdotal claims of using bacteria found in yogurt are also being investigated toward reducing the symptoms of inflammatory bowel disease such as Crohn’s disease and ulcerative colitis, reported in The Economist November 3rd, 2012 at France’s National Institute of Health and Medical Research  by Nathalie Vergnolle in Science Translational Medicine. One of the causes within bowel inflammation are the elastase enzymes which degrade the proteins responsible for maintaining the elastic nature within the gut wall. There’s that shape maintenance factor again being invoked by these researchers without citing the tension net itself within the gut wall. Elafin production, which inhibits elastase has been found in lower quantities during bowel inflammation. Gene additives coding for elafin were tagged onto two regular yogurt bacteria Lactococcus lactis and Lactobacillus casei then loaded into mice with inflamed bowels. Bowel inflammation markers called cytokines  had their levels of production drop to normal levels in addition the mice guts appearances also returned to normal. According to Natalie Vergnolle she has already mixed human colitis cells with her elafin coded yogurt bacteria to in her words successfully, ….” calm down the colitis bacteria cells.”

The Economist article ends optimistically with the following hope. ” If these (bacterial coded elfin mimicking proteins) do work, they may be avenues for the bacterial treatment of other conditions linked to gut bacteria. These include obesity, diabetes and even possibly, autism. A new era of bacterial medicine could thus be about to dawn.”

As the reader may have noticed my wife’s eye operation occurred one week ago. So I have been actively thinking about wound healing during her convalescence as I have been at her side during this long week. She spoke great words yesterday, ” I can see the details of my fingernails before the shapes were mere forms.” These words were very intense for both of us as it means her eye is healing. So here is some final thoughts on healing and shape.

As tissue heals the tissue is drawn into itself as it shrinks. Part of the apparatus of the protein complex accomplishing this is at the resolution of tension held within the tissue zone around the wound. We have all seen our own skin cuts, no matter where they are, do this puckering dance of repair. As edges of tissue approximate to the surgeons cuts, tissue integrity is reestablished yet the scar is the final product of the repair. So inside the eye the retina is repositioned into its preferred position, and fingernail detail in a returned vision sense brings tears of excitement.

In my recent essay on Sopite Syndrome I revealed the distressing eye trauma being experienced by returning astronauts from their space missions. The post space flight MRI’s have revealed the deformed shape of the eyes of the astronauts once back on Earth’s surface. Eyes deformed are eyes tension stretched perhaps from the gravity changes they experienced. But as we have seen with wound healing the drawn tissue surfaces, be they in the gut or within the eye change the integrity of the cellular architecture especially the tension within these tissues, what I call, Snelson’s tensio natat. Inflammation is a process of recognition of surface features that mimic the guts bacterial mix revealing the hostile bacteria interacting with the friendly bacteria, within the structure of the gut wall elasticity. What is important for our understanding is the tension language that exists within eye tissue or within gut tissue as a tension language we must learn to interpret in all its complexity and detail. That’s what my wife’s eye surgery has taught me this week, to keep learning the language of tensio natat within our multitudes of connected cellular networks. Within the hidden trusses of tension/compression of those connected cellular networks I ask myself: do they become the anatomical cross sections revealing to become images of eye or gut performing as distributed linking within coherent webs of elasticity ? It takes astronauts who venture outside the confines of our gravity vector to reveal the importance of the shape of their eye to perform its sensing. My wife during her healing has had to lie face down for two weeks to allow the substituted gas bubble inserted into her eye allowing gravity to help press against her retina toward proper healing. Tensegrity as floating tension nets within cell assemblies are the only structures that also can be constructed to hold their shape outside of a gravity field. Tensegrity assembly also imposes the chirality of a left compared to a right side to shapes. The healing eye needs gravity as much as a loving husband to join the tissues together. The healing process is outside of our planet Earth in terms of design and assembly. What this means is my mission trying to bring meaning toward understanding my chosen domain of unraveling brain concussions. Studying the eye in all its complexity  brings meaning into the overlap of harmony that becomes imposed within the functioning of the neural structures as the brain shape shifts after concussion forces have passed. It has been a year now that I have begun to probe this question seriously. The damaged eye of my wife has opened my eye into new directions, that is the message I am offering toward better detail as the meaning unravels before me.

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About cerebrovortex

Montreal Grandmother, Agnes Kent was saved by Raul Wallenberg from certain death, when he provided papers for her and her Mom to escape away from the Nazis. Today when asked what that escape meant, she replied,"Remind people, that while statesmen and whole countries remained silent and did nothing, a single individual chose to act, with ramifications that proved enormous. Similar choices confront us today. Write that simple truth she said, it can never be repeated often enough because the world keeps forgetting it."
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